7 April 2024 08:33
القاهرة, مصر

EGP0

Chinese name nonapeptide-1
English name (2S)-1-[(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2R)-2 -[[(2S)-1-[(2S)-2-amino-4-methylsulfanyl-butanoyl]pyrrolidine-2-carbonyl]amino]-3-phenyl-propanoyl]amino]-5-guanidino-pentanoyl]amino] -3-(1H-indol-3-yl)propanoyl]amino]-3-phenyl-propanoyl]amino]hexanoyl]-N-[(1S)-1-carbamoyl-2-methyl-propyl]pyrrolidine-2-carboxamide
Chinese alias: Nine-peptide-1 | Meilitide | Whitening peptide English alias： (S)-1-(L-methionyl)-N-((R)-1-(((S)-1-(((R)-1-(((S)-1-(((S)-6-amino-1-((S)-2-(((S)-1-amino-3-methyl-1-oxobutan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxohexan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide
Nonapeptide-1
Melitane
H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2
L-Methionyl-L-prolyl-D-phenylalanyl-L-arginyl-D-tryptophyl-L-phenylalanyl-L-lysyl-L-prolyl-L-valinamide
Melanostatine
Nonapeptide-1 (melanostatin-5) is a peptide hormone and a selective antagonist of MC1R (Ki: 40nM). Nonapeptide-1 is a competitive α-MSH antagonist that can effectively inhibit α-MSH-induced intracellular cAMP and melanosome dispersion in melanocytes (IC50 is 2.5nM and 11nM, respectively). Nonapeptide-1 inhibits melanin synthesis and can be used to study skin pigmentation, regulation of adrenal steroidogenesis, and skin cancer.